• Big data research: epidemiology and pharmacoepidemiology
• Risk prediction modelling
• Health and health service research including cost-effectiveness analysis

1. Eric YF Wan, Anna HY Mok, Vincent KC Yan, Boyuan Wang, Ran Zhang, Sabrina N Hong, Celine SL Chui, Xue Li, Carlos KH Wong, Francisco TT Lai, Kathryn CB Tan, CS Lau, Ian CK Wong*, Esther WY Chan*. Vaccine effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 Omicron BA.2 infection, hospitalisation, severe complications, cardiovascular disease and mortality in patients with diabetes mellitus: A case control study. Journal of Infection. 2022. (in press) (IF=38.637, 4/95 in Infectious diseases)
2. Eric YF Wan, Yuan Wang, Celine SL Chui, Anna HY Mok, Wanchun Xu, Vincent KC Yan, Francisco TT Lai, Xue Li, Carlos KH Wong, Esther WY Chan, Kui-Kai Lau, Benjamin J Cowling, Ivan FN Hung, Ian CK Wong. Safety of an inactivated, whole-virion COVID-19 vaccine (CoronaVac) in people aged 60 years or older in Hong Kong: a modified self-controlled case series. The Lancet Healthy Longevity. 2022; 3(7):e491-e500. doi: 10.1016/S2666-7568(22)00125-8 (1/67 in Geriatrics & Gerontology)
3. Eric YF Wan, Celine SL Chui, Vanessa WS Ng, Yuan Wang, Vincent KC Yan, Ivan CH Lam, Min Fan, Francisco TT Lai, Esther WY Chan, Xue Li, Carlos KH Wong, Raccoon KC Chung, Benjamin J Cowling, Wing C Fong, Alexander YL Lau, Vincent CT Mok, Frank LF Chan, Cheuk K Lee, Lot ST Chan, Dawin Lo, Kui K Lau, Ivan FN Hung, Chak S Lau, Gabriel M Leung, Ian CK Wong. mRNA (BNT162b2) COVID-19 vaccination increased risk of Bell’s palsy: a nested case control and self-controlled case series study. Clinical Infectious Diseases. 2022. doi: 10.1093/cid/ciac460 (IF 20.999, 7/161 in Immunology)
   
4. Eric YF Wan, Celine SL Chui, Yuan Wang, Vanessa WS Ng, Vincent KC Yan, Francisco TT Lai, Xue Li, Carlos KH Wong, Esther WY Chan, Christina SM Wong, Kathy SM Leung, Michael Y Ni, Sophie A Valkenburg, Joseph S Malik Peiris, Joseph TK Wu, Benjamin J Cowling, Darren M Ashcroft, Ivan FN Hung, Gabriel M Leung, Ian CK Wong. Herpes zoster related hospitalization after inactivated (CoronaVac) and mRNA (BNT162b2) SARS-CoV-2 vaccination: a self-controlled case series and nested case-control study. The Lancet Regional Health - Western Pacific. 2022. DOI:10.1016/j.lanwpc.2022.100393 (IF 8.559, 3/109 in Health Care Sciences & Services)
   
5. Kam S Chan, Eric YF Wan*, Weng-Yee Chin, Esther YT Yu, Ivy L Mak, Will HG Cheng, Margaret K Ho, Cindy LK Lam. Association between team-based continuity of care and risk of cardiovascular diseases among patients with diabetes: a retrospective cohort study. Diabetes Care. 2022 (IF 17.152, 6/146 in Endocrinology & Metabolism)
6.  Eric YF Wan, Celine SL Chui, Francisco TT Lai, Esther WY Chan, Xue Li, Vincent KC Yan, Le Gao, Qiuyan Yu, Ivan CH Lam, Raccoon KC Chung, Benjamin J Cowling, WC Fong, Alexander YL Lau, Vincent CT Mok, Frank LF Chan, CK Lee, Lot ST Chan, Dawin Lo, KK Lau, Ivan FN Hung, Gabriel M Leung, Ian CK Wong. Analysis of Bell's Palsy Following Vaccination with mRNA (Comirnaty) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study. The Lancet Infectious Diseases. 2021. (IF 71.421, 2/94 in Infectious diseases)
7. Eric YF Wan, Weng-Yee Chin, Esther YT Yu, Ian CK Wong, Esther WY Chan, Shirley X Li, Nico KL Cheung, Y Wang, Cindy LK Lam. The impact of cardiovascular disease and chronic kidney disease on life expectancy and direct medical cost in a 10-year diabetes cohort study. Diabetes Care. 2020; doi: https://doi.org/10.2337/dc19-2137 (IF 17.152, 6/146 in Endocrinology & Metabolism)
8. Eric YF Wan, Wing-Tung Fung, C Mary Schooling, Shiu Lun Au Yeung, Man-Ki Kwok, Esther YT Yu, Yuan Wang, Esther WY Chan, Ian CK Wong, Cindy LK Lam. Blood pressure and Risk of Cardiovascular disease in UK Biobank: A Mendelian randomization study. Hypertension. 2020. (IF 9.897, 8/67 in Peripheral vascular disease)
9. Eric YF Wan, Esther YT Yu, Weng-Yee Chin, Daniel YT Fong, Edmond PH Choi, Cindy LK Lam. Association of Blood Pressure and risk of Cardiovascular and Chronic Kidney Disease in Hong Kong Hypertensive Patients. Hypertension. 2019; 74(2):331-40; doi: 10.1161/HYPERTENSIONAHA.119.13123 (IF 9.897, 8/67 in Peripheral vascular disease)
10. Eric YF Wan, Esther YT Yu, Weng-Yee Chin, Daniel YT Fong, Edmond PH Choi, Eric HM Tang, Cindy LK Lam. Burden of CKD and Cardiovascular Disease on Life Expectancy and Health Service Utilization: a Cohort Study of Hong Kong Chinese Hypertensive Patients. Journal of the American Society of Nephrology. 2019; 30 (10) 1991-1999; doi: 10.1681/ASN.2018101037 (IF 14.978; 5/90 in UROLOGY & NEPHROLOGY).
11. Eric YF Wan, Esther YT Yu, Weng-Yee Chin, Colman SC Fung, Daniel YT Fong, Edmond PH Choi, Anca KC Chan, Cindy LK Lam. Effect of Achieved Systolic Blood Pressure on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus - A Population-based Retrospective Cohort Study. Diabetes Care. 2018; 41 (6): 1134-1141 DOI: https://doi.org/10.2337/dc17-2443. (IF 17.152, 6/146 in Endocrinology & Metabolism)
12.  Eric YF Wan, Colman SC Fung, Frances FF Jiao, Esther YT Yu, Weng-Yee Chin, Daniel YT Fong, Carlos KH Wong, Anca KC Chan, Karina HY Chan, Ruby LP Kwok, Cindy LK Lam. Five-Year Effectiveness of the Multidisciplinary Risk Assessment and Management Programme–Diabetes Mellitus (RAMP-DM) on Diabetes-Related Complications and Health Service Uses—A Population-Based and Propensity-Matched Cohort Study. Diabetes Care 2018; 41:49-59 doi: 10.2337/dc17-0426 (IF 17.152, 6/146 in Endocrinology & Metabolism)
13. Eric YF Wan, Colman SC Fung, Esther YT Yu, Daniel YT Fong, Julie Y Chan, Cindy LK Lam. Association of Visit-to-visit variability of Systolic Blood Pressure with Cardiovascular Diseases and Mortality in Chinese Patients with Type 2 Diabetes Mellitus – A Retrospective Population-based Cohort Study. Diabetes Care 2016 doi:10.2337/dc16-1617 (IF 17.152, 6/146 in Endocrinology & Metabolism)
14. Eric YF Wan, Colman SC Fung, Esther YT Yu, Daniel YT Fong, Weng-Yee Chin, Andrew KC Chan, Cindy LK Lam. Do we need a Patient-centred Target for Systolic Blood Pressure in Hypertensive Patients With Type 2 Diabetes Mellitus? Hypertension 2017; 70 (Nov):1273-1282. DOI: 10.1161/HYPERTENSIONAHA.117.10034. (IF 9.897, 8/67 in Peripheral vascular disease)
15.  Eric YF Wan, Colman SC Fung, Carlos KH Wong, Weng-Yee Chin, Cindy LK Lam. Association of Hemoglobin A1c Levels With Cardiovascular Disease and Mortality in Chinese Patients With Diabetes. Journal of the American College of Cardiology 2016 67(4), 456-458. doi: 10.1016/j.jacc.2015.11.020 (IF 27.203, 5/207 in Cardiac & cardiovascular system)

Principal Investigator

1. P-I, “Optimizing the frequency of complication monitoring for patients with Type 2 diabetes mellitus in primary care based on risk stratification”. National Natural Science Foundation of China (NSFC) Excellent Young Scientists Fund (Hong Kong and Macau) CNY ¥ 2,000,000 Start date: 1 Jan 2023 End date: 31 Dec 2025.
2. P-I of “The development of the Common Core course “Health Literacy: Things to know before consulting Dr. Google”. HKU Common Core Teaching Development Grant (TDG) Award HK$80,000. Start date: 13 Dec 2021 End date: 31 Dec 2021.
3. Co P-I of “The long term spill-over impact of COVID-19 on health and healthcare of patients with non-communicable diseases: an in-depth outcome and health economic evaluation. Food and Health Bureau Commissioned Research on the Novel Coronavirus Disease (COVID-19). HK$9,334,600. Start date: 1 Apr 2021 End date: 30 Jun 2026.
4. Co-PI. of “A multinational big data Covid-19 Epidemiological Study on post-infection Outcomes (ACESO). RGC Collaborative Research Fund (CRF) Coronavirus Disease (COVID-19) and Novel Infectious Disease (NID) Research Exercise.” HK$9,691,060. #C7154-20G. Start date: 1 Jun 2021 End date: 31 Dec 2023.
5. P-I of “What is optimal blood pressure target for antihypertensive treatment? A target randomized controlled trial emulation using big data.” Health and Medical Research Fund. HK$925,260. Start date: 1 Dec 2021 End date: 30 Nov 2023.
6. P-I of “When should statin therapy be initiated for patients with diabetes mellitus - A target randomized controlled trial emulation using big data.”. Health and Medical Research Fund Research Fellowship Scheme HK$1,135,398. Start date: 1 Nov 2020 End date: 30 Oct 2022.
7. P-I of “Pilot study on the association between blood pressure and risk of vascular and non-vascular diseases”. Seed Fund for Basic Research #201906159003 HK$149,886. Start date: Jun 2019 End date: Jun 2021.
8. P-I of “Identifying and articulating the student learning experience in the MBBS 130 curriculum Enrichment Year”. HKU Teaching Development Grant (TDG) Award HK$100,000. Start date: Sep 2019 End date: Aug 2020.

Co-Investigator

1. Co-I of “COVID-19 vaccines Adverse events Response and Evaluation (CARE) Programme” Food and Health Bureau Commissioned Research on the Novel Coronavirus Disease (COVID-19). # COVID19F01. HK$10,000,000. Start date: 1 Apr 2021 End date: 31 Mar 2024.
2. Co-I of “Association between the use of different classes of blood pressure lowering drugs and risk of incident dementia: a multidatabase study” (P.I. Celine Chui, Research Grants Council #17113720, HKSAR, HK$694,305) Start date: Sep 2020 End date: Feb 2023
3. Co-I of “Cardiovascular risk prediction model for patients on lipid modifying drugs” (P.I. Celine Chui, Innovation and Technology Fund, Partnership Research Programme, HK$ 3,047,842) Start date: Dec 2020 End date: Nov 2022
4. Co-I of “Cohort study to investigate the outcomes of patients with hypertension and/or diabetes mellitus and the effectiveness and cost-effectiveness of structured multi-disciplinary intervention programmes” (P.I Cindy LK Lam, Health and Health Services Research Fund Commissioned Research to Support Local Cohorts and Follow-up Studies (CFS-HKU4, HK$5,999,020) Start date: Aug 2019 End date: Jul 2024
5. Co-I of “The safe use of dating applications (apps) among men who have sex with men: developing and testing an interactive web-based intervention to reduce risky sexual behaviours” (P.I. EPH Choi, Research Grants Council Early Career Scheme Grant # 27607518 from Research Grants Council, HKSAR, HK$877,176) Start date: Jan 2019 End date: Dec 2021
6. Co-I of “The unmet needs, symptoms distress and psychosocial profile of Chines patients with prostate cancer, a prospective longitudinal study” (P.I. EPH Choi, Enhanced New Staff Start-up Research Grant HK$380,000) Start date: June 2018 End date: May 2021
7. Co-I of “In-depth exploration of a bidirectional parent-child health relationship and its mediating and moderating factors among low-income families in Hong Kong” (P.I. EYT Yu, Health and Medical Research Fund #14151571 from The Food and Health Bureau, HKSAR) HK$1,200,000 Start date: 01/08/2017; End date: 31/07/2019
8. Co-I of “10-year risk predication models of complications and mortality of DM in Chinese patients in primary care in HK” (P.I. CLK LAM, Health and Medical Research Fund #14151181 from The Food and Health Bureau, HKSAR) HK$1,200,000 Start date: 01/07/2017; End date: 30/06/2019

1. National Natural Science Foundation of China (NSFC) Excellent Young Scientists Fund (Hong Kong and Macau), 2022
2. Faculty of Medicine Outstanding Research Output Award, 2022 (as First author)
3. Outstanding Poster Presentation Award at Hong Kong Primary Care Conference 2021. (as co-author)
4. Best Oral Presentation Award at Hong Kong Primary Care Conference 2021. (as co-author)
5. The Hong Kong College of Family Physicians Best Research 2020 (as co-author)
6. Best Research Paper Award Hong Kong Primary Care Conference 2020 (as First author)
7. The Hong Kong College of Family Physicians Best Research 2019 (as First author)
8. Faculty of Medicine Outstanding Research Output Award, 2019 (as First author)
9. Best Research Paper Award Hong Kong Primary Care Conference 2019 (as co-author)
10. Best Poster Award, 7th Asia Pacific Primary Care Research Conference 2019 (as co-author)
11. Best Contribution to Family Medicine Award World Organization of Family Doctors (WONCA), 2018 (as First author)
12. 1st Distinguished Research Making Family Medicine Shine Award World Organization of Family Doctors (WONCA), 2018 (as First author)
13. Hong Kong College of Family Physicians Best Research Award, 2017 (as co-author)
14. Hong Kong College of Family Physicians Best Research Award, 2016 (as co-author)
15. Best Poster Presentation Award the 6th Hong Kong International Nursing Forum, 2015 (as First author)
16. Distinguished Paper Award North American Primary Care Research Group (NAPCRG) Annual Meeting,2014 (as co-author)